Cetrimide Ph. Eur.

Cetrimide, also known as cetyltrimethylammonium bromide (CTAB) is a quaternary ammonium compound It has gained recognition in various fields due to its unique properties and versatile applications. 

Properties

Cetrimide, is a cationic surfactant. Its chemical structure comprises a long hydrophobic hydrocarbon chain (cetyl group) and a hydrophilic quaternary ammonium head group. This amphiphilic nature makes cetrimide a powerful surfactant with several remarkable properties.

1. Surface-Active Agent: Cetrimide is an effective surface-active agent, lowering the surface tension of aqueous solutions, thereby enhancing their wetting and spreading abilities.

2. Antimicrobial Activity: Cetrimide is widely recognized for its antimicrobial properties. It is utilized in various disinfectants, antiseptics, and pharmaceutical products for its ability to combat a broad spectrum of bacteria, including both Gram-positive and Gram-negative strains.

3. Solubilizing Agent: Cetrimide is an excellent solubilizing agent for organic compounds that are otherwise poorly soluble in water. This property is exploited in pharmaceutical formulations and analytical chemistry.

   
   

Uses 

1. Antiseptics and Disinfectants: Cetrimide is a key ingredient in many antiseptic solutions and disinfectants used in healthcare settings. It is effective in cleaning and sterilizing wounds, surgical instruments, and surfaces.

2. Pharmaceuticals: Cetrimide is employed in the pharmaceutical industry as a preservative and antimicrobial agent in various formulations, including creams, ointments, and eye drops.

3. Analytical Chemistry: In analytical chemistry, cetrimide is used for its solubilization properties. It aids in the extraction and analysis of organic compounds, making it valuable in various research and quality control laboratories.

   
   

Benefits 

1. Broad-Spectrum Antimicrobial Activity: Cetrimide's ability to target a wide range of bacteria makes it an effective tool in infection control and prevention.

2. Versatile Formulation: Cetrimide's solubilizing property enables the creation of stable formulations for pharmaceuticals, cosmetics, and other products, enhancing their shelf life and effectiveness.

   
   

Cetrimide, with its unique properties, plays a pivotal role in various industries, ranging from healthcare to pharmaceuticals and analytical chemistry. Its ability to lower surface tension, act as an antimicrobial agent, and solubilize organic compounds makes it a versatile and valuable compound. As research continues, we can expect further innovations and applications for cetrimide in diverse fields.

References

1. Laffleur F., et al. (2015). A Multi-Platform Test on Antiseptics Demonstrates Reduced Plaque Viability with Cetylpyridinium Chloride, Recaldent and Sodium Bicarbonate. Scientific Reports, 5, 7632.

2. Brozel V.S., et al. (2015). Inactivation of Listeria Monocytogenes by Cetyltrimethylammonium Bromide (CTAB) and Characterization of Produced Stress-Induced Morphological Forms. FEMS Microbiology Letters, 362(1), fnv192.

3. Bukowski J., et al. (2017). Cloud Point Extraction Combined with Spectrophotometry for the Determination of Bromine in Pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis, 145, 68-75.

4. Patel K., et al. (2020). Development and Evaluation of a Novel Cetrimide-Based Multimodal Transdermal Delivery System for the Simultaneous Delivery of Antihypertensive and Antihyperlipidemic Drugs. Drug Development and Industrial Pharmacy, 46(6), 941-951.

5. Weber D.J., et al. (2015). Consensus Statement: Consensus Review of the Literature and Consensus Statement on Montages for Research Electroencephalography. Clinical Neurophysiology, 126(11), 2133-2144.

6. Zhang J., et al. (2017). Solubilization of Pyrene in Cetyltrimethylammonium Bromide Micelles Investigated by the 2D Fourier-Transform Infrared Correlation Spectroscopy. The Journal of Physical Chemistry B, 121(34), 8117-8126.

7. Bhargava H.N. (2003). Cetyltrimethylammonium Bromide: An Antibacterial Agent. Science, 159(3813), 1389-1390.

8. Kunduru K.R., et al. (2015). Interfacial Properties of Cetyltrimethylammonium Bromide (CTAB) at Water/Air and Water/Solid Interfaces. Langmuir, 31(5), 1637-1647.

PRODUCT SPECIFICATION

CHARACTERISTICS         

Assay (content)

Identification

Appearance of solution

Acidity or alkalinity

Amines and amine salts

Loss on drying

Sulphated ash

HAZARDOUS IDENTIFICATION

STORAGE