Specialty dermatology raw material
Podophyllum resin, also known as podophyllin, is a plant-derived resin obtained from the rhizomes and roots of Podophyllum species. It is a complex mixture of active lignans, with podophyllotoxin as its best-known biologically active component. Podophyllum resin has long been used in topical dermatological preparations because of its antimitotic and caustic action on wart tissue.
Podophyllum resin, also known as podophyllin, is a plant-derived resin obtained from the rhizomes and roots of Podophyllum species. It is a complex mixture of active lignans, with podophyllotoxin as its best-known biologically active component. Podophyllum resin has long been used in topical dermatological preparations because of its antimitotic and caustic action on wart tissue.
In dermatology, podophyllum resin is used in topical regulated formulations for the specialist external dermatology formulations, especially external genital and perianal warts. Its action is based on destruction of visible wart tissue and inhibition of cell division. Podophyllum resin is intended for external topical use only and is typically applied under controlled professional conditions.
Highly refined Podophyllotoxin in conformity with Ph. Eur. specification is also available.
Supply context
BHM Chemicals is a supplier of high quality BP grade Podophyllum Resin.
Minimum order quantity: 25 kg
Podophyllum Resin BP is a well-established dermatology ingredient used in topical specialist external dermatology formulations. It remains relevant as a traditional plant-derived active material for controlled external use in specialist dermatological applications. Because podophyllum resin is a crude botanical resin containing podophyllotoxin and related lignans, it is valued mainly for topical dermatology use rather than for general pharmaceutical use across multiple dosage forms.
Podophyllum resin is a natural resinous extract obtained from Podophyllum plant material. It contains a mixture of lignans and related compounds, with podophyllotoxin regarded as the principal active constituent responsible for its biological activity.
The activity of podophyllum resin is linked mainly to podophyllotoxin, which interferes with cell division by acting on microtubule formation. This is the basis of its use in the topical management of wart tissue and other abnormal epithelial growths.
Podophyllum resin is used in topical external-use preparations, commonly in solutions containing 10-25% podophyllum resin for professional application. These preparations are applied carefully to the lesion and then washed off after a defined period.
Podophyllum resin is used in dermatology regulated formulations intended for the specialist external dermatology formulations, especially external genital and perianal warts. It acts locally on visible wart tissue and is used as a topical specialist product use rather than a systemic regulated product use.
Podophyllum resin preparations are generally used under specialist or professional supervision because of their potency and toxicity. specialist product use is limited to small external areas, and the product should not be applied to open lesions, bleeding tissue, or large affected surfaces.
Podophyllum resin is also important as a botanical source of podophyllotoxin, a lignan that has major pharmaceutical relevance. Podophyllotoxin is used directly in topical specialist external dermatology formulations, and its derivatives have also served as the basis for important anticancer regulated products such as etoposide and teniposide.
Podophyllum resin is a potent and toxic material and should be handled with care. It is intended for external use only. Excessive application or application to damaged tissue can lead to significant local irritation and systemic toxicity. Use during pregnancy is contraindicated, and contact with healthy skin and mucous membranes should be avoided.
Podophyllum Resin BP is a specialized dermatology ingredient with established use in topical preparations for the specialist external dermatology formulations. Its value lies in its plant-derived origin, podophyllotoxin content, and well-known antimitotic activity. For manufacturers of topical dermatological products, Podophyllum Resin BP remains an important raw material for controlled external-use formulations.
BHM Chemicals
| Parameter | Specification |
|---|---|
| CAS No. | 9000-55-9 |
| Synonyms | Podophyllin Resin, Podophyllum Hexandrum Resin, Podophylline |
| Characteristics | An amorphous powder varying in colour from light brown to greenish yellow, or brownish grey masses. Partly soluble in hot water, from which it is precipitated on cooling, in ether and in 5M ammonia. |
| Content | Minimum 50% of Podophyllum Resin |
| Identification | Complies with BP test |
| Matter insoluble in ethanol (96%) | The residue weighs not more than 25 mg |
| Matter insoluble in 5M ammonia | The residue weighs not less than 0.18 gm and not more than 0.30 gm |
| Loss on drying | Maximum 5.0% |
| Ash content | Maximum 1.0% |
Full documentation is available on request. Product suitability should be assessed by the customer for the intended application.
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