Metronidazole Ph. Eur.
VETERINARY ACTIVE INGREDIENT
CAS no. 443-48-1 (Metronidazole)
CAS no. 13182-89-3 (Metronidazole Benzoate)
Metronidazole belongs to a class of drugs called antibiotic and antiprotozoal.
In veterinary it is widely used to treat infections of Giardia in dogs, cats, and other companion animals as well as for the management of chronic inflammatory bowel disease. Metronidazole medications are also used for treatment of systemic and/or gastrointestinal clostridial infections in horses.
BHM Chemicals is a supplier of Ph. Eur. quality Metronidazole and Metronidazole Benzoate suitable for use in veterinary preparations.
Minimum order quantity: 25kg
Metronidazole Ph. Eur.
PRODUCT SPECIFICATION
CHARACTERISTICS
Assay
Identification
Melting point
Appearance of solution
Any impurity
Total impurities
Heavy metals
Loss on drying
Sulphated ash
HAZARDOUS IDENTIFICATION
STORAGE
White or yellowish, crystalline powder. Slightly soluble in water, in acetone, in alcohol and in methylene chloride.
99.0% to 101.0% (dried basis)
Conforms to Ph. Eur. Tests
159 °C to 163 °C
As per Ph. Eur.test: The solution is not more opalescent than reference suspension II and not more intensely coloured than reference solution GY6
Not more than 0.1%
Not more than 0.2%
Not more than 20ppm
Not more than 0.5%
Not more than 0.1%
Non-hazardous chemical
Keep container tightly closed in a cool and dry place and protected from light. Protect from contamination by foreign substances.
Metronidazole Benzoate Ph. Eur.
PRODUCT SPECIFICATION
CHARACTERISTICS
Content
Identification
Melting point
Appearance of solution
Acidity
Heavy metals
Loss on drying
Sulphated ash
Impurity A (Metronidazole)
Impurity B (2-methyl-4-nitroimidazole)
Impurity C (benzoic acid)
Other impurities
Total impurities
HAZARDOUS IDENTIFICATION
STORAGE
White or slightly yellowish, crystalline powder or flakes. Practically insoluble in water, freely soluble in methylene chloride, soluble in acetone, slightly soluble in alcohol.
98.5% to 101.0% (dried basis)
Conforms to Ph. Eur. tests
99oC – 102oC
As per Ph. Eur. test: The solution is not more opalescent than reference suspension II and not more intensely coloured than reference solution GY₃
As per Ph. Eur. test: Not more than 0.25 ml of 0.02 M sodium hydroxide is required to change the colour of the indicator
Not more than 20ppm
Not more than 0.5%
Not more than 0.1%
Not more than 0.1%
Not more than 0.1%
Not more than 0.1%
Not more than 0.1% (each)
Not more than 0.2%
Non-hazardous chemical
Keep container tightly closed in a cool and dry place and protected from light. Protect from contamination by foreign substances.